Enantio- and regioselective CuH-catalyzed hydroamination of alkenes.
نویسندگان
چکیده
A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hydroamination products.
منابع مشابه
Design of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 135 42 شماره
صفحات -
تاریخ انتشار 2013